Ontology highlight
ABSTRACT:
SUBMITTER: Jackson MS
PROVIDER: S-EPMC2768475 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Inorganic chemistry 20091001 19
Parkinson's disease has been long linked to environmental factors, such as transition metals and recently to alpha-synuclein, a presynaptic protein. Using tryptophan-containing peptides, we identified the minimal Cu(II)-binding sequence to be within the first four residues, MDV(F/W), anchored by the alpha-amino terminus. In addition, mutant peptide 1-10 (Lys --> Arg) verified that neither Lys6 nor Lys10 are necessary for Cu(II) binding. Interestingly, Trp4 excited-state decay kinetics measured f ...[more]