Ontology highlight
ABSTRACT:
SUBMITTER: Goudarzi A
PROVIDER: S-EPMC4850424 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Goudarzi Afsaneh A Zhang Di D Huang He H Barral Sophie S Kwon Oh Kwang OK Qi Shankang S Tang Zhanyun Z Buchou Thierry T Vitte Anne-Laure AL He Tieming T Cheng Zhongyi Z Montellier Emilie E Gaucher Jonathan J Curtet Sandrine S Debernardi Alexandra A Charbonnier Guillaume G Puthier Denis D Petosa Carlo C Panne Daniel D Rousseaux Sophie S Roeder Robert G RG Zhao Yingming Y Khochbin Saadi S
Molecular cell 20160401 2
Recently discovered histone lysine acylation marks increase the functional diversity of nucleosomes well beyond acetylation. Here, we focus on histone butyrylation in the context of sperm cell differentiation. Specifically, we investigate the butyrylation of histone H4 lysine 5 and 8 at gene promoters where acetylation guides the binding of Brdt, a bromodomain-containing protein, thereby mediating stage-specific gene expression programs and post-meiotic chromatin reorganization. Genome-wide mapp ...[more]