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Two endogenous retroviral loci appear to contribute to Multiple Sclerosis.

ABSTRACT: Two endogenous retroviral loci seem to be involved in the human disease Multiple sclerosis (MS).The two retroviral loci synergize in and contribute to MS (shown by ANOVA). Synergy probably means recombination or complementation of the activated viruses. Similar observations may be true for Type 1 Diabetes and Rheumatoid arthritis. In MS the genes also synergize with the immune system; this could well be a common phenomenon.We formulate various theories about the role of the viruses. Also, the concept is developing that some forms of autoimmunity should be treatable with antiretrovirals. In the case of MS, this idea is gradually gaining weight.

SUBMITTER: Nexo BA

PROVIDER: S-EPMC4851805 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature

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Two endogenous retroviral loci appear to contribute to Multiple Sclerosis.

Nexø Bjørn A BA Jensen Sara B SB Nissen Kari K KK Hansen Bettina B Laska Magdalena J MJ

BMC neurology 20160430

<h4>Background</h4>Two endogenous retroviral loci seem to be involved in the human disease Multiple sclerosis (MS).<h4>Results</h4>The two retroviral loci synergize in and contribute to MS (shown by ANOVA). Synergy probably means recombination or complementation of the activated viruses. Similar observations may be true for Type 1 Diabetes and Rheumatoid arthritis. In MS the genes also synergize with the immune system; this could well be a common phenomenon.<h4>Conclusion</h4>We formulate variou ...[more]

PMID: 27130045

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