Ontology highlight
ABSTRACT:
SUBMITTER: Lundberg SM
PROVIDER: S-EPMC4852466 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Lundberg Scott M SM Tu William B WB Raught Brian B Penn Linda Z LZ Hoffman Michael M MM Lee Su-In SI
Genome biology 20160430
A cell's epigenome arises from interactions among regulatory factors-transcription factors and histone modifications-co-localized at particular genomic regions. We developed a novel statistical method, ChromNet, to infer a network of these interactions, the chromatin network, by inferring conditional-dependence relationships among a large number of ChIP-seq data sets. We applied ChromNet to all available 1451 ChIP-seq data sets from the ENCODE Project, and showed that ChromNet revealed previousl ...[more]