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Substrate specificity of FUT8 and chemoenzymatic synthesis of core-fucosylated asymmetric N-glycans.

ABSTRACT: Substrate specificity studies of human FUT8 using 77 structurally-defined N-glycans as acceptors showed a strict requirement towards the ?1,3-mannose branch, but a great promiscuity towards the ?1,6-mannose branch. Accordingly, a chemoenzymatic strategy was developed for the efficient synthesis of core-fucosylated asymmetric N-glycans.

SUBMITTER: Calderon AD 

PROVIDER: S-EPMC4852481 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature

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Substrate specificity of FUT8 and chemoenzymatic synthesis of core-fucosylated asymmetric N-glycans.

Calderon Angie D AD   Liu Yunpeng Y   Li Xu X   Wang Xuan X   Chen Xi X   Li Lei L   Wang Peng G PG  

Organic & biomolecular chemistry 20160401 17

Substrate specificity studies of human FUT8 using 77 structurally-defined N-glycans as acceptors showed a strict requirement towards the α1,3-mannose branch, but a great promiscuity towards the α1,6-mannose branch. Accordingly, a chemoenzymatic strategy was developed for the efficient synthesis of core-fucosylated asymmetric N-glycans. ...[more]

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