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Chemoenzymatic synthesis of ?-dystroglycan core M1 O-mannose glycans.

ABSTRACT: The diversity-oriented chemoenzymatic synthesis of ?-dystroglycan (?-DG) core M1 O-mannose glycans has been achieved via a three-step sequential one-pot multienzyme (OPME) glycosylation of a chemically prepared disaccharyl serine intermediate. The high flexibility and efficiency of this chemoenzymatic strategy was demonstrated for the synthesis of three more complex core M1 O-mannose glycans for the first time along with three previously reported core M1 structures.

SUBMITTER: Zhang Y

PROVIDER: S-EPMC4617230 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature

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Chemoenzymatic synthesis of α-dystroglycan core M1 O-mannose glycans.

Zhang Yan Y Meng Caicai C Jin Lan L Chen Xi X Wang Fengshan F Cao Hongzhi H

Chemical communications (Cambridge, England) 20150623 58

The diversity-oriented chemoenzymatic synthesis of α-dystroglycan (α-DG) core M1 O-mannose glycans has been achieved via a three-step sequential one-pot multienzyme (OPME) glycosylation of a chemically prepared disaccharyl serine intermediate. The high flexibility and efficiency of this chemoenzymatic strategy was demonstrated for the synthesis of three more complex core M1 O-mannose glycans for the first time along with three previously reported core M1 structures. ...[more]

PMID: 26100261

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