Ontology highlight
ABSTRACT:
SUBMITTER: Chiang NJ
PROVIDER: S-EPMC4853728 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Chiang Nai-Jung NJ Hsu Chiun C Chen Jen-Shi JS Tsou Hsiao-Hui HH Shen Ying-Ying YY Chao Yee Y Chen Ming-Huang MH Yeh Ta-Sen TS Shan Yan-Shen YS Huang Shiu-Feng SF Chen Li-Tzong LT
Scientific reports 20160503
Aberrant expression of ROS1, ALK or c-MET (RAM) is implicated in carcinogenesis and cancer drug resistance. We retrospectively evaluated the effect of RAM expression on outcomes for advanced biliary tract cancer patients, who were treated with gemcitabine plus oxaliplatin (GEMOX), with or without cetuximab, in a randomized phase II trial. RAM expression levels on archived tissue sections were scored using immunohistochemistry (IHC). Of 110 tumors with IHC staining for all three markers, 18 were ...[more]