Ontology highlight
ABSTRACT:
SUBMITTER: Tulsyan S
PROVIDER: S-EPMC4854269 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Tulsyan Sonam S Mittal Rama Devi RD Mittal Balraj B
Pharmacogenomics and personalized medicine 20160427
The ABCB1 gene encodes a permeability glycoprotein, which is one of the most extensively studied human adenosine-triphosphate (ATP)-dependent efflux transporters. Permeability glycoprotein is expressed in the apical membranes of tissues such as intestine, liver, blood-brain barrier, kidney, placenta, and testis and contributes to intracellular drug disposition. It is also highly expressed in tumor cells conferring drug resistance, which is one of the major problems in the efficacy of cancer chem ...[more]