Ontology highlight
ABSTRACT:
SUBMITTER: Peethambaram P
PROVIDER: S-EPMC3110393 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Peethambaram Prema P Fridley Brooke L BL Vierkant Robert A RA Larson Melissa C MC Kalli Kimberly R KR Elliott Elaine A EA Oberg Ann L AL White Kristin L KL Rider David N DN Keeney Gary L GL Cunningham Julie M JM Hartmann Lynn C LC Goode Ellen L EL
International journal of molecular epidemiology and genetics 20110502 2
Using the most comprehensive approach to selecting polymorphisms to date, we sought to examine whether time to recurrence in ovarian cancer was associated with common inherited variation in eight genes involved in drug metabolism, multi-drug resistance, or DNA repair, namely ABCB1, CYP2C8, CYP3A4, ERCC1, ERCC2, GSTM1, XPC, and XRCC1. Invasive epithelial ovarian cancer patients (N=445) seen at the Mayo Clinic from 1999 to 2009 with 275 observed recurrences or deaths were analyzed at 94 SNPs in th ...[more]