Application of Good's buffers to pH imaging using hyperpolarized (13)C MRI.
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ABSTRACT:
SUBMITTER: Flavell RR
PROVIDER: S-EPMC4854286 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Publications
Application of Good's buffers to pH imaging using hyperpolarized (13)C MRI.
Flavell Robert R RR von Morze Cornelius C Blecha Joseph E JE Korenchan David E DE Van Criekinge Mark M Sriram Renuka R Gordon Jeremy W JW Chen Hsin-Yu HY Subramaniam Sukumar S Bok Robert A RA Wang Zhen J ZJ Vigneron Daniel B DB Larson Peder E PE Kurhanewicz John J Wilson David M DM
Chemical communications (Cambridge, England) 20150901 74
N-(2-Acetamido)-2-aminoethanesulfonic acid (ACES), one of Good's buffers, was applied to pH imaging using hyperpolarized (13)C magnetic resonance spectroscopy. Rapid NMR- and MRI-based pH measurements were obtained by exploiting the sensitive pH-dependence of its (13)C chemical shift within the physiologic range. ...[more]
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