[(11)C]Ascorbic and [(11)C]dehydroascorbic acid, an endogenous redox pair for sensing reactive oxygen species using positron emission tomography.
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ABSTRACT:
SUBMITTER: Carroll VN
PROVIDER: S-EPMC4854297 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
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[(11)C]Ascorbic and [(11)C]dehydroascorbic acid, an endogenous redox pair for sensing reactive oxygen species using positron emission tomography.
Carroll V N VN Truillet C C Shen B B Flavell R R RR Shao X X Evans M J MJ VanBrocklin H F HF Scott P J H PJ Chin F T FT Wilson D M DM
Chemical communications (Cambridge, England) 20160310 27
Here we report the radiosynthesis of an endogenous redox pair, [(11)C]ascorbic acid ([(11)C]VitC) and [(11)C]dehydroascorbic acid ([(11)C]DHA), the reduced and oxidized forms of vitamin C, and their application to ROS sensing. These results provide the basis for in vivo detection of ROS using positron emission tomography (PET). ...[more]
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