Ontology highlight
ABSTRACT:
SUBMITTER: Tauchert MJ
PROVIDER: S-EPMC4854570 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Tauchert Marcel J MJ Ficner Ralf R
Acta crystallographica. Section F, Structural biology communications 20160422 Pt 5
Prp28 (pre-mRNA-splicing ATP-dependent RNA helicase 28) is a spliceosomal DEAD-box helicase which is involved in two steps of spliceosome assembly. It is required for the formation of commitment complex 2 in an ATP-independent manner as well as for the formation of the pre-catalytic spliceosome, which in contrast is ATP-dependent. During the latter step, Prp28 is crucial for the integration of the U4/U6·U5 tri-snRNP since it displaces the U1 snRNP and allows the U6 snRNP to base-pair with the 5' ...[more]