Ontology highlight
ABSTRACT:
SUBMITTER: Chen JY
PROVIDER: S-EPMC4854608 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Chen James Y JY Miyanishi Masanori M Wang Sean K SK Yamazaki Satoshi S Sinha Rahul R Kao Kevin S KS Seita Jun J Sahoo Debashis D Nakauchi Hiromitsu H Weissman Irving L IL
Nature 20160201 7589
Haematopoietic stem cells (HSCs) are arguably the most extensively characterized tissue stem cells. Since the identification of HSCs by prospective isolation, complex multi-parameter flow cytometric isolation of phenotypic subsets has facilitated studies on many aspects of HSC biology, including self-renewal, differentiation, ageing, niche, and diversity. Here we demonstrate by unbiased multi-step screening, identification of a single gene, homeobox B5 (Hoxb5, also known as Hox-2.1), with expres ...[more]