Ontology highlight
ABSTRACT:
SUBMITTER: Ding L
PROVIDER: S-EPMC3270376 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Ding Lei L Saunders Thomas L TL Enikolopov Grigori G Morrison Sean J SJ
Nature 20120125 7382
Several cell types have been proposed to create niches for haematopoietic stem cells (HSCs). However, the expression patterns of HSC maintenance factors have not been systematically studied and no such factor has been conditionally deleted from any candidate niche cell. Thus, the cellular sources of these factors are undetermined. Stem cell factor (SCF; also known as KITL) is a key niche component that maintains HSCs. Here, using Scf(gfp) knock-in mice, we found that Scf was primarily expressed ...[more]