Ontology highlight
ABSTRACT:
SUBMITTER: Bell CC
PROVIDER: S-EPMC4855186 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Bell Catherine C CC Hendriks Delilah F G DF Moro Sabrina M L SM Ellis Ewa E Walsh Joanne J Renblom Anna A Fredriksson Puigvert Lisa L Dankers Anita C A AC Jacobs Frank F Snoeys Jan J Sison-Young Rowena L RL Jenkins Rosalind E RE Nordling Åsa Å Mkrtchian Souren S Park B Kevin BK Kitteringham Neil R NR Goldring Christopher E P CE Lauschke Volker M VM Ingelman-Sundberg Magnus M
Scientific reports 20160504
Liver biology and function, drug-induced liver injury (DILI) and liver diseases are difficult to study using current in vitro models such as primary human hepatocyte (PHH) monolayer cultures, as their rapid de-differentiation restricts their usefulness substantially. Thus, we have developed and extensively characterized an easily scalable 3D PHH spheroid system in chemically-defined, serum-free conditions. Using whole proteome analyses, we found that PHH spheroids cultured this way were similar ...[more]