Ontology highlight
ABSTRACT:
SUBMITTER: Tiosano D
PROVIDER: S-EPMC4856077 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Tiosano Dov D Audi Laura L Climer Sharlee S Zhang Weixiong W Templeton Alan R AR Fernández-Cancio Monica M Gershoni-Baruch Ruth R Sánchez-Muro José Miguel JM El Kholy Mohamed M Hochberg Zèev Z
G3 (Bethesda, Md.) 20160503 5
The well-documented latitudinal clines of genes affecting human skin color presumably arise from the need for protection from intense ultraviolet radiation (UVR) vs. the need to use UVR for vitamin D synthesis. Sampling 751 subjects from a broad range of latitudes and skin colors, we investigated possible multilocus correlated adaptation of skin color genes with the vitamin D receptor gene (VDR), using a vector correlation metric and network method called BlocBuster. We discovered two multilocus ...[more]