Ontology highlight
ABSTRACT:
SUBMITTER: Smith HE
PROVIDER: S-EPMC4856081 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Smith Harold E HE Fabritius Amy S AS Jaramillo-Lambert Aimee A Golden Andy A
G3 (Bethesda, Md.) 20160503 5
Whole-genome sequencing provides a rapid and powerful method for identifying mutations on a global scale, and has spurred a renewed enthusiasm for classical genetic screens in model organisms. The most commonly characterized category of mutation consists of monogenic, recessive traits, due to their genetic tractability. Therefore, most of the mapping methods for mutation identification by whole-genome sequencing are directed toward alleles that fulfill those criteria (i.e., single-gene, homozygo ...[more]