Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC4856546 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Liu Yan Y Wang Yin Y Du Zhanwen Z Yan Xiaoli X Zheng Pan P Liu Yang Y
Cell reports 20160421 5
Fbxo30 is an orphan member of the F-box protein family with no known substrate or function. Here we report that, while Fbxo30(-/-) mice exhibit normal development, growth, lifespan, and fertility, the females fail to nurture their offspring as a result of defective mammopoiesis. Mass spectrometry analysis of Fbxo30-associated proteins revealed that Fbxo30 specifically interacts with the bipolar spindle kinesin EG5 (encoded by Kif11). As a result, Fbxo30 targets Eg5 for ubiquitinylation and contr ...[more]