Ontology highlight
ABSTRACT:
SUBMITTER: Madireddy A
PROVIDER: S-EPMC4856979 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Madireddy Advaitha A Purushothaman Pravinkumar P Loosbroock Christopher P CP Robertson Erle S ES Schildkraut Carl L CL Verma Subhash C SC
Nucleic acids research 20160202 8
Kaposi's sarcoma associated herpesvirus (KSHV) establishes life-long latent infection by persisting as an extra-chromosomal episome in the infected cells and by maintaining its genome in dividing cells. KSHV achieves this by tethering its epigenome to the host chromosome by latency associated nuclear antigen (LANA), which binds in the terminal repeat (TR) region of the viral genome. Sequence analysis of the TR, a GC-rich DNA element, identified several potential Quadruplex G-Rich Sequences (QGRS ...[more]