Ontology highlight
ABSTRACT:
SUBMITTER: Yip KT
PROVIDER: S-EPMC4858652 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Yip King Tuo KT Zhong Xue Yin XY Seibel Nadia N Pütz Stefanie S Autzen Jasmin J Gasper Raphael R Hofmann Eckhard E Scherkenbeck Jürgen J Stoll Raphael R
Scientific reports 20160506
Melanoma inhibitory activity (MIA), an extracellular protein highly expressed by malignant melanoma cells, plays an important functional role in melanoma development, progression, and metastasis. After its secretion, MIA directly interacts with extracellular matrix proteins, such as fibronectin (FN). By this mechanism, MIA actively facilitates focal cell detachment from surrounding structures and strongly promotes tumour cell invasion and migration. Hence, the molecular understanding of MIA's fu ...[more]