Ontology highlight
ABSTRACT:
SUBMITTER: Sima LE
PROVIDER: S-EPMC6548576 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Sima Livia Elena LE Yakubov Bakhtiyor B Zhang Sheng S Condello Salvatore S Grigorescu Arabela A AA Nwani Nkechiyere G NG Chen Lan L Schiltz Gary E GE Arvanitis Constandina C Zhang Zhong-Yin ZY Matei Daniela D
Molecular cancer therapeutics 20190423 6
Tissue transglutaminase (TG2) is a multifunctional protein with enzymatic, GTP-ase, and scaffold properties. TG2 interacts with fibronectin (FN) through its N-terminus domain, stabilizing integrin complexes, which regulate cell adhesion to the matrix. Through this mechanism, TG2 participates in key steps involved in metastasis in ovarian and other cancers. High-throughput screening identified several small molecule inhibitors (SMI) for the TG2/FN complex. Rational medicinal chemistry optimizatio ...[more]