Ontology highlight
ABSTRACT:
SUBMITTER: Le TP
PROVIDER: S-EPMC4859069 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Le Thao Phuong TP Vuong Linh Thuong LT Kim Ah-Ram AR Hsu Ya-Chieh YC Choi Kwang-Wook KW
Nature communications 20160506
14-3-3 family proteins regulate multiple signalling pathways. Understanding biological functions of 14-3-3 proteins has been limited by the functional redundancy of conserved isotypes. Here we provide evidence that 14-3-3 proteins regulate two interacting components of Tor signalling in Drosophila, translationally controlled tumour protein (Tctp) and Rheb GTPase. Single knockdown of 14-3-3ɛ or 14-3-3ζ isoform does not show obvious defects in organ development but causes synergistic genetic inter ...[more]