Ontology highlight
ABSTRACT:
SUBMITTER: Stroebel D
PROVIDER: S-EPMC4859819 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Stroebel David D Buhl Derek L DL Knafels John D JD Chanda Pranab K PK Green Michael M Sciabola Simone S Mony Laetitia L Paoletti Pierre P Pandit Jayvardhan J
Molecular pharmacology 20160224 5
N-methyl-d-aspartate receptors (NMDARs) are glutamate-gated ion channels that play key roles in brain physiology and pathology. Because numerous pathologic conditions involve NMDAR overactivation, subunit-selective antagonists hold strong therapeutic potential, although clinical successes remain limited. Among the most promising NMDAR-targeting drugs are allosteric inhibitors of GluN2B-containing receptors. Since the discovery of ifenprodil, a range of GluN2B-selective compounds with strikingly ...[more]