Ontology highlight
ABSTRACT:
SUBMITTER: Zhang YK
PROVIDER: S-EPMC4860574 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Zhang Yun-Kai YK Zhang Guan-Nan GN Wang Yi-Jun YJ Patel Bhargav A BA Talele Tanaji T TT Yang Dong-Hua DH Chen Zhe-Sheng ZS
Scientific reports 20160509
ATP-Binding Cassette transporters are involved in the efflux of xenobiotic compounds and are responsible for decreasing drug accumulation in multidrug resistant (MDR) cells. Discovered by structure-based virtual screening algorithms, bafetinib, a Bcr-Abl/Lyn tyrosine kinase inhibitor, was found to have inhibitory effects on both ABCB1- and ABCG2-mediated MDR in this in-vitro investigation. Bafetinib significantly sensitized ABCB1 and ABCG2 overexpressing MDR cells to their anticancer substrates ...[more]