Ontology highlight
ABSTRACT:
SUBMITTER: Shaffer CV
PROVIDER: S-EPMC4860899 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Shaffer Corena V CV Cai Shengxin S Peng Jiangnan J Robles Andrew J AJ Hartley Rachel M RM Powell Douglas R DR Du Lin L Cichewicz Robert H RH Mooberry Susan L SL
Journal of natural products 20160119 3
There remains a critical need for more effective therapies for the treatment of late-stage and metastatic prostate cancers. Three Texas native plants yielded three new and three known compounds with antiproliferative and cytotoxic activities against prostate cancer cells with IC50 values in the range of 1.7-35.0 μM. A new sesquiterpene named espadalide (1), isolated from Gochnatia hypoleuca, had low micromolar potency and was highly effective in clonogenic assays. Two known bioactive germacranol ...[more]