Ontology highlight
ABSTRACT:
SUBMITTER: Ogunsina M
PROVIDER: S-EPMC7037447 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Ogunsina Makanjuola M Samadder Pranati P Idowu Temilolu T Nachtigal Mark M Schweizer Frank F Arthur Gilbert G
Molecules (Basel, Switzerland) 20200128 3
A major impediment to successful cancer treatment is the inability of clinically available drugs to kill drug-resistant cancer cells. We recently identified metabolically stable L-glucosamine-based glycosylated antitumor ether lipids (GAELs) that were cytotoxic to chemotherapy-resistant cancer cells. In the absence of commercially available L-glucosamine, many steps were needed to synthesize the compound and the overall yield was poor. To overcome this limitation, a facile synthetic procedure us ...[more]