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The neurogenetics of alternative splicing.

ABSTRACT: Alternative precursor-mRNA splicing is a key mechanism for regulating gene expression in mammals and is controlled by specialized RNA-binding proteins. The misregulation of splicing is implicated in multiple neurological disorders. We describe recent mouse genetic studies of alternative splicing that reveal its critical role in both neuronal development and the function of mature neurons. We discuss the challenges in understanding the extensive genetic programmes controlled by proteins that regulate splicing, both during development and in the adult brain.

SUBMITTER: Vuong CK

PROVIDER: S-EPMC4861142 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature

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The neurogenetics of alternative splicing.

Vuong Celine K CK Black Douglas L DL Zheng Sika S

Nature reviews. Neuroscience 20160501 5

Alternative precursor-mRNA splicing is a key mechanism for regulating gene expression in mammals and is controlled by specialized RNA-binding proteins. The misregulation of splicing is implicated in multiple neurological disorders. We describe recent mouse genetic studies of alternative splicing that reveal its critical role in both neuronal development and the function of mature neurons. We discuss the challenges in understanding the extensive genetic programmes controlled by proteins that regu ...[more]

PMID: 27094079

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