Ontology highlight
ABSTRACT:
SUBMITTER: Zea DJ
PROVIDER: S-EPMC8327911 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Zea Diego Javier DJ Laskina Sofya S Baudin Alexis A Richard Hugues H Laine Elodie E
Genome research 20210615 8
Understanding how protein function has evolved and diversified is of great importance for human genetics and medicine. Here, we tackle the problem of describing the whole transcript variability observed in several species by generalizing the definition of splicing graph. We provide a practical solution to construct parsimonious evolutionary splicing graphs where each node is a minimal transcript building block defined across species. We show a clear link between the functional relevance, tissue ...[more]