Chemotaxis-driven assembly of endothelial barrier in a tumor-on-a-chip platform.
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ABSTRACT:
SUBMITTER: Aung A
PROVIDER: S-EPMC4862883 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Publications
Chemotaxis-driven assembly of endothelial barrier in a tumor-on-a-chip platform.
Aung Aereas A Theprungsirikul Jomkuan J Lim Han Liang HL Varghese Shyni S
Lab on a chip 20160421 10
The integration of three-dimensional micropatterning with microfluidics provides a unique opportunity to create perfusable tissue constructs in vitro. Herein, we have used this approach to create a tumor-on-a-chip with an endothelial barrier. Specifically, we photopatterned a mixture of endothelial cells and cancer spheroids within a gelatin methacrylate (GelMA) hydrogel inside a microfluidic device. The differential motility of endothelial and cancer cells in response to a controlled morphogen ...[more]
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