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Association of polymorphisms at the microRNA binding site of the caprine KITLG 3'-UTR with litter size.

ABSTRACT: This study identified three novel single nucleotide polymorphisms (SNPs) (c.1389C?>?T, c.1457A?>?C and c.1520G?>?A) in the caprine KITLG 3'-UTR through DNA sequencing. The three SNP loci were closely linked in Guanzhong dairy (GD) goats. Two alleles of the c.1457A?>?C SNP introduced two miRNA sites (chi-miR-204-5p and chi-miR-211). Individuals with combined genotype TT-CC-AA had a higher litter size compared with those with combined genotypes CC-AA-GG, TC-CC-GA and CC-AC-GG (P??T, c.1457A?>?C and c.1520G?>?A account for differences in the litter size of GD goats because chi-miR-204-5p and chi-miR-211 could change the expression levels of the KITLG gene and reduce GC proliferation.

SUBMITTER: An X

PROVIDER: S-EPMC4863368 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature

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Association of polymorphisms at the microRNA binding site of the caprine KITLG 3'-UTR with litter size.

An Xiaopeng X Song Yuxuan Y Bu Shuhai S Ma Haidong H Gao Kexin K Hou Jinxing J Wang Shan S Lei Zhang Z Cao Binyun B

Scientific reports 20160511

This study identified three novel single nucleotide polymorphisms (SNPs) (c.1389C > T, c.1457A > C and c.1520G > A) in the caprine KITLG 3'-UTR through DNA sequencing. The three SNP loci were closely linked in Guanzhong dairy (GD) goats. Two alleles of the c.1457A > C SNP introduced two miRNA sites (chi-miR-204-5p and chi-miR-211). Individuals with combined genotype TT-CC-AA had a higher litter size compared with those with combined genotypes CC-AA-GG, TC-CC-GA and CC-AC-GG (P < 0.05). Luciferas ...[more]

PMID: 27168023

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