Ontology highlight
ABSTRACT:
SUBMITTER: Zaborowska J
PROVIDER: S-EPMC4863834 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Positive transcription elongation factor b (P-TEFb), which comprises cyclin-dependent kinase 9 (CDK9) kinase and cyclin T subunits, is an essential kinase complex in human cells. Phosphorylation of the negative elongation factors by P-TEFb is required for productive elongation of transcription of protein-coding genes by RNA polymerase II (pol II). In addition, P-TEFb-mediated phosphorylation of the carboxyl-terminal domain (CTD) of the largest subunit of pol II mediates the recruitment of transc ...[more]