HIF3A association with adiposity: the story begins before birth.
Ontology highlight
ABSTRACT:
SUBMITTER: Pan H
PROVIDER: S-EPMC4863876 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
HIF3A association with adiposity: the story begins before birth.
Pan Hong H Lin Xinyi X Wu Yonghui Y Chen Li L Teh Ai Ling AL Soh Shu E SE Lee Yung Seng YS Tint Mya Thway MT MacIsaac Julia L JL Morin Alexander M AM Tan Kok Hian KH Yap Fabian F Saw Seang Mei SM Kobor Michael S MS Meaney Michael J MJ Godfrey Keith M KM Chong Yap-Seng YS Gluckman Peter D PD Karnani Neerja N Holbrook Joanna D JD
Epigenomics 20150526 6
<h4>Aim</h4>Determine if the association of HIF3A DNA methylation with weight and adiposity is detectable early in life.<h4>Material & methods</h4>We determined HIF3A genotype and DNA methylation patterns (on hybridization arrays) in DNA extracted from umbilical cords of 991 infants. Methylation levels at three CpGs in the HIF3A first intron were related to neonatal and infant anthropometry and to genotype at nearby polymorphic sites.<h4>Results & conclusion</h4>Higher methylation levels at thre ...[more]
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