Ontology highlight
ABSTRACT:
SUBMITTER: Gao Y
PROVIDER: S-EPMC4864289 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Gao Yifang Y Rae William W Ramakrishnan Keseva Ananth KA Barcenas-Morales Gabriela G Döffinger Rainer R Eren Efrem E Faust Saul N SN Ottensmeier Christian H CH Williams Anthony P AP
PloS one 20160511 5
The recently described Mucosal Associated Invariant T (MAIT) cells mediate specific recognition of bacterial and fungal vitamin B2 metabolites. As innate T cells, they possess broad effector responses, including IFN- including Iproduction, that are comparable to conventional T cell responses. Immunodeficiencies associated with systemic Th17 deficiency may also be compounded by defects in MAIT immunity. We evaluated Th17 immunity in this innate T cell compartment in primary (AD-HIES) and secondar ...[more]