Ontology highlight
ABSTRACT:
SUBMITTER: Sundstrom P
PROVIDER: S-EPMC6497460 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Sundström Patrik P Szeponik Louis L Ahlmanner Filip F Sundquist Malin M Wong Justin S B JSB Lindskog Elinor Bexe EB Gustafsson Bengt B Quiding-Järbrink Marianne M
Oncotarget 20190419 29
Mucosal-associated invariant T (MAIT) cells all express a semi-invariable T cell receptor recognizing microbial metabolites presented on the MHC class I-like molecule MR1. Upon activation, they rapidly secrete cytokines and increase their cytotoxic potential. We showed recently that MAIT cells with Th1 phenotype accumulate in human colon adenocarcinomas. Here, we investigated the cytotoxic potential of tumor-infiltrating MAIT cells in colon adenocarcinomas, and to what extent it may be affected ...[more]