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PepPSy: a web server to prioritize gene products in experimental and biocuration workflows.


ABSTRACT: Among the 20 000 human gene products predicted from genome annotation, about 3000 still lack validation at protein level. We developed PepPSy, a user-friendly gene expression-based prioritization system, to help investigators to determine in which human tissues they should look for an unseen protein. PepPSy can also be used by biocurators to revisit the annotation of specific categories of proteins based on the 'omics' data housed by the system. In this study, it was used to prioritize 21 dubious protein-coding genes among the 616 annotated in neXtProt for reannotation. PepPSy is freely available at http://peppsy.genouest.orgDatabase URL: http://peppsy.genouest.org.

SUBMITTER: Sallou O 

PROVIDER: S-EPMC4865363 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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PepPSy: a web server to prioritize gene products in experimental and biocuration workflows.

Sallou Olivier O   Duek Paula D PD   Darde Thomas A TA   Collin Olivier O   Lane Lydie L   Chalmel Frédéric F  

Database : the journal of biological databases and curation 20160512


Among the 20 000 human gene products predicted from genome annotation, about 3000 still lack validation at protein level. We developed PepPSy, a user-friendly gene expression-based prioritization system, to help investigators to determine in which human tissues they should look for an unseen protein. PepPSy can also be used by biocurators to revisit the annotation of specific categories of proteins based on the 'omics' data housed by the system. In this study, it was used to prioritize 21 dubiou  ...[more]

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