Ontology highlight
ABSTRACT:
SUBMITTER: Materne P
PROVIDER: S-EPMC4865366 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
eLife 20160512
In fission yeast, the ste11 gene encodes the master regulator initiating the switch from vegetative growth to gametogenesis. In a previous paper, we showed that the methylation of H3K4 and consequent promoter nucleosome deacetylation repress ste11 induction and cell differentiation (Materne et al., 2015) but the regulatory steps remain poorly understood. Here we report a genetic screen that highlighted H2B deubiquitylation and the RSC remodeling complex as activators of ste11 expression. Mechani ...[more]