Human OCT2 variant c.808G>T confers protection effect against cisplatin-induced ototoxicity.

ABSTRACT:

Aim

Assuming that genetic variants of the SLC22A2 and SLC31A1 transporter affect patients' susceptibility to cisplatin-induced ototoxicity, we compared the distribution of 11 SLC22A2 variants and the SLC31A1 variant rs10981694 between patients with and without cisplatin-induced ototoxicity.

Patients & methods

Genotyping was performed in 64 pediatric patients and significant findings were re-evaluated in 66 adults.

Results

The SLC22A2 polymorphism rs316019 (c.808G>T; Ser270Ala) was significantly associated with protection from cisplatin-induced ototoxicity in the pediatric (p = 0.022) and the adult cohort (p = 0.048; both: Fisher's exact test). This result was confirmed by multiple logistic regression analysis accounting for age which was identified as a relevant facto

SUBMITTER: Lanvers-Kaminsky C 

PROVIDER: S-EPMC4865798 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature