Ontology highlight
ABSTRACT:
SUBMITTER: Callejo A
PROVIDER: S-EPMC5606684 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Callejo Angela A Sedó-Cabezón Lara L Juan Ivan Domènech ID Llorens Jordi J
Toxics 20150715 3
Cisplatin is a highly effective chemotherapeutic agent that is widely used to treat solid organ malignancies. However, serious side effects have been associated with its use, such as bilateral, progressive, irreversible, dose-dependent neurosensory hearing loss. Current evidence indicates that cisplatin triggers the production of reactive oxygen species in target tissues in the inner ear. A variety of agents that protect against cisplatin-induced ototoxicity have been successfully tested in cell ...[more]