Ontology highlight
ABSTRACT:
SUBMITTER: Miyawaki S
PROVIDER: S-EPMC4866046 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Miyawaki Shingo S Kawamura Yoshimi Y Oiwa Yuki Y Shimizu Atsushi A Hachiya Tsuyoshi T Bono Hidemasa H Koya Ikuko I Okada Yohei Y Kimura Tokuhiro T Tsuchiya Yoshihiro Y Suzuki Sadafumi S Onishi Nobuyuki N Kuzumaki Naoko N Matsuzaki Yumi Y Narita Minoru M Ikeda Eiji E Okanoya Kazuo K Seino Ken-Ichiro K Saya Hideyuki H Okano Hideyuki H Miura Kyoko K
Nature communications 20160510
The naked mole-rat (NMR, Heterocephalus glaber), which is the longest-lived rodent species, exhibits extraordinary resistance to cancer. Here we report that NMR somatic cells exhibit a unique tumour-suppressor response to reprogramming induction. In this study, we generate NMR-induced pluripotent stem cells (NMR-iPSCs) and find that NMR-iPSCs do not exhibit teratoma-forming tumorigenicity due to the species-specific activation of tumour-suppressor alternative reading frame (ARF) and a disruption ...[more]