Universal allosteric mechanism for G? activation by GPCRs.
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ABSTRACT:
SUBMITTER: Flock T
PROVIDER: S-EPMC4866443 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Publications
Universal allosteric mechanism for Gα activation by GPCRs.
Flock Tilman T Ravarani Charles N J CNJ Sun Dawei D Venkatakrishnan A J AJ Kayikci Melis M Tate Christopher G CG Veprintsev Dmitry B DB Babu M Madan MM
Nature 20150706 7564
G protein-coupled receptors (GPCRs) allosterically activate heterotrimeric G proteins and trigger GDP release. Given that there are ∼800 human GPCRs and 16 different Gα genes, this raises the question of whether a universal allosteric mechanism governs Gα activation. Here we show that different GPCRs interact with and activate Gα proteins through a highly conserved mechanism. Comparison of Gα with the small G protein Ras reveals how the evolution of short segments that undergo disorder-to-order ...[more]
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