Ontology highlight
ABSTRACT:
SUBMITTER: Ji X
PROVIDER: S-EPMC3833828 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Ji Xiaoyun X Wu Ying Y Yan Junpeng J Mehrens Jennifer J Yang Haitao H DeLucia Maria M Hao Caili C Gronenborn Angela M AM Skowronski Jacek J Ahn Jinwoo J Xiong Yong Y
Nature structural & molecular biology 20131020 11
SAMHD1, a dNTP triphosphohydrolase (dNTPase), has a key role in human innate immunity. It inhibits infection of blood cells by retroviruses, including HIV, and prevents the development of the autoinflammatory Aicardi-Goutières syndrome (AGS). The inactive apo-SAMHD1 interconverts between monomers and dimers, and in the presence of dGTP the protein assembles into catalytically active tetramers. Here, we present the crystal structure of the human tetrameric SAMHD1-dGTP complex. The structure revea ...[more]