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Cytokine kinetics of Zika virus-infected patients from acute to reconvalescent phase.

ABSTRACT: Zika virus is an emerging mosquito-borne flavivirus currently causing large epidemics in the Pacific Ocean region and Brazil. Clinically, Zika fever resembles dengue fever, but is less severe. Whereas the clinical syndrome and laboratory diagnostic procedures have been described, little attention was paid to the immunology of the disease and its possible use for clinical follow-up of patients. Here, we investigate the role of cytokines in the pathogenesis of Zika fever in travelers returning from Asia, the Pacific, and Brazil. Polyfunctional T cell activation (Th1, Th2, Th9, and Th17 response) was seen during the acute phase characterized by respective cytokine level increases, followed by a decrease in the reconvalescent phase.

SUBMITTER: Tappe D

PROVIDER: S-EPMC4867002 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

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Cytokine kinetics of Zika virus-infected patients from acute to reconvalescent phase.

Tappe Dennis D Pérez-Girón José Vicente JV Zammarchi Lorenzo L Rissland Jürgen J Ferreira Davis F DF Jaenisch Thomas T Gómez-Medina Sergio S Günther Stephan S Bartoloni Alessandro A Muñoz-Fontela César C Schmidt-Chanasit Jonas J

Medical microbiology and immunology 20151224 3

Zika virus is an emerging mosquito-borne flavivirus currently causing large epidemics in the Pacific Ocean region and Brazil. Clinically, Zika fever resembles dengue fever, but is less severe. Whereas the clinical syndrome and laboratory diagnostic procedures have been described, little attention was paid to the immunology of the disease and its possible use for clinical follow-up of patients. Here, we investigate the role of cytokines in the pathogenesis of Zika fever in travelers returning fro ...[more]

PMID: 26702627

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Viral and serological kinetics in Zika virus-infected patients in South Korea.

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Project description:PolyA+ RNA sequencing of Zika virus-infected human brain organoids at 5 days post-infection.

2017-04-03 | E-MTAB-4811 | biostudies-arrayexpress

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Postnatal Zika virus infection of nonhuman primate infants born to mothers infected with homologous Brazilian Zika virus.

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