Ontology highlight
ABSTRACT:
SUBMITTER: Fader L
PROVIDER: S-EPMC4867477 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
ACS medicinal chemistry letters 20160301 5
A high-throughput screen based on a viral replication assay was used to identify inhibitors of the human cytomegalovirus. Using this approach, hit compound 1 was identified as a 4 μM inhibitor of HCMV that was specific and selective over other herpes viruses. Time of addition studies indicated compound 1 exerted its antiviral effect early in the viral life cycle. Mechanism of action studies also revealed that this series inhibited infection of MRC-5 and ARPE19 cells by free virus and via direct ...[more]