Ontology highlight
ABSTRACT:
SUBMITTER: De Rosa V
PROVIDER: S-EPMC4868085 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
De Rosa Veronica V Galgani Mario M Porcellini Antonio A Colamatteo Alessandra A Santopaolo Marianna M Zuchegna Candida C Romano Antonella A De Simone Salvatore S Procaccini Claudio C La Rocca Claudia C Carrieri Pietro Biagio PB Maniscalco Giorgia Teresa GT Salvetti Marco M Buscarinu Maria Chiara MC Franzese Adriana A Mozzillo Enza E La Cava Antonio A Matarese Giuseppe G
Nature immunology 20150928 11
Human regulatory T cells (T(reg) cells) that develop from conventional T cells (T(conv) cells) following suboptimal stimulation via the T cell antigen receptor (TCR) (induced T(reg) cells (iT(reg) cells)) express the transcription factor Foxp3, are suppressive, and display an active proliferative and metabolic state. Here we found that the induction and suppressive function of iT(reg) cells tightly depended on glycolysis, which controlled Foxp3 splicing variants containing exon 2 (Foxp3-E2) thro ...[more]