Ontology highlight
ABSTRACT:
SUBMITTER: Wohlfert EA
PROVIDER: S-EPMC3204837 | biostudies-other | 2011 Nov
REPOSITORIES: biostudies-other
Wohlfert Elizabeth A EA Grainger John R JR Bouladoux Nicolas N Konkel Joanne E JE Oldenhove Guillaume G Ribeiro Carolina Hager CH Hall Jason A JA Yagi Ryoji R Naik Shruti S Bhairavabhotla Ravikiran R Paul William E WE Bosselut Remy R Wei Gang G Zhao Keji K Oukka Mohamed M Zhu Jinfang J Belkaid Yasmine Y
The Journal of clinical investigation 20111003 11
Tregs not only keep immune responses to autoantigens in check, but also restrain those directed toward pathogens and the commensal microbiota. Control of peripheral immune homeostasis by Tregs relies on their capacity to accumulate at inflamed sites and appropriately adapt to their local environment. To date, the factors involved in the control of these aspects of Treg physiology remain poorly understood. Here, we show that the canonical Th2 transcription factor GATA3 is selectively expressed in ...[more]