Ontology highlight
ABSTRACT:
SUBMITTER: Yabe S
PROVIDER: S-EPMC4868474 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Yabe Shinichiro S Alexenko Andrei P AP Amita Mitsuyoshi M Yang Ying Y Schust Danny J DJ Sadovsky Yoel Y Ezashi Toshihiko T Roberts R Michael RM
Proceedings of the National Academy of Sciences of the United States of America 20160405 19
Human embryonic stem cells (ESCs) readily commit to the trophoblast lineage after exposure to bone morphogenetic protein-4 (BMP-4) and two small compounds, an activin A signaling inhibitor and a FGF2 signaling inhibitor (BMP4/A83-01/PD173074; BAP treatment). During differentiation, areas emerge within the colonies with the biochemical and morphological features of syncytiotrophoblast (STB). Relatively pure fractions of mononucleated cytotrophoblast (CTB) and larger syncytial sheets displaying th ...[more]