Ontology highlight
ABSTRACT:
SUBMITTER: Kalaora S
PROVIDER: S-EPMC4868674 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Kalaora Shelly S Barnea Eilon E Merhavi-Shoham Efrat E Qutob Nouar N Teer Jamie K JK Shimony Nilly N Schachter Jacob J Rosenberg Steven A SA Besser Michal J MJ Admon Arie A Samuels Yardena Y
Oncotarget 20160201 5
The antigenicity of cells is demarcated by the peptides bound by their Human Leucocyte Antigen (HLA) molecules. Through this antigen presentation, T cell specificity response is controlled. As a fraction of the expressed mutated peptides is presented on the HLA, these neo-epitopes could be immunogenic. Such neo-antigens have recently been identified through screening for predicted mutated peptides, using synthetic peptides or ones expressed from minigenes, combined with screening of patient tumo ...[more]