Ontology highlight
ABSTRACT:
SUBMITTER: Cong X
PROVIDER: S-EPMC4868984 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Scientific reports 20160517
The Stac3 gene is exclusively expressed in skeletal muscle, and Stac3 knockout is perinatal lethal in mice. Previous data from Stac3-deleted diaphragms indicated that Stac3-deleted skeletal muscle could not contract because of defective excitation-contraction (EC) coupling. In this study, we determined the contractility of Stac3-deleted hindlimb muscle. In response to frequent electrostimulation, Stac3-deleted hindlimb muscle contracted but the maximal tension generated was only 20% of that in c ...[more]