Ontology highlight
ABSTRACT:
SUBMITTER: Strakova A
PROVIDER: S-EPMC4869914 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
eLife 20160517
Canine transmissible venereal tumour (CTVT) is a clonally transmissible cancer that originated approximately 11,000 years ago and affects dogs worldwide. Despite the clonal origin of the CTVT nuclear genome, CTVT mitochondrial genomes (mtDNAs) have been acquired by periodic capture from transient hosts. We sequenced 449 complete mtDNAs from a global population of CTVTs, and show that mtDNA horizontal transfer has occurred at least five times, delineating five tumour clades whose distributions tr ...[more]