Augmentation of Recipient Adaptive Alloimmunity by Donor Passenger Lymphocytes within the Transplant.
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ABSTRACT:
SUBMITTER: Harper IG
PROVIDER: S-EPMC4870521 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Publications
Augmentation of Recipient Adaptive Alloimmunity by Donor Passenger Lymphocytes within the Transplant.
Harper Ines G IG Ali Jason M JM Harper Simon J F SJ Wlodek Elizabeth E Alsughayyir Jawaher J Negus Margaret C MC Qureshi M Saeed MS Motalleb-Zadeh Reza R Saeb-Parsy Kourosh K Bolton Eleanor M EM Bradley J Andrew JA Clatworthy Menna R MR Conlon Thomas M TM Pettigrew Gavin J GJ
Cell reports 20160428 6
Chronic rejection of solid organ allografts remains the major cause of transplant failure. Donor-derived tissue-resident lymphocytes are transferred to the recipient during transplantation, but their impact on alloimmunity is unknown. Using mouse cardiac transplant models, we show that graft-versus-host recognition by passenger donor CD4 T cells markedly augments recipient cellular and humoral alloimmunity, resulting in more severe allograft vasculopathy and early graft failure. This augmentatio ...[more]
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Project description: Not available
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